MCF10DCIS.com Xenograft Model of Human Comedo Ductal Carcinoma In Situ
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چکیده
منابع مشابه
MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ.
Ductal carcinoma in situ (DCIS) is becoming increasingly common, accounting for 25%–30% of newly diagnosed cases of breast cancer (1). The comedo type represents about 40% of the cases and carries the worst prognosis (2). The subsequent incidence of recurrence in patients presenting previously with comedo DCIS was 20% compared with 5% for noncomedo DCIS in one study (3). National Surgical Adjuv...
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Here we present a series of infiltrative ductal carcinoma breast cases (infiltrative ductal carcinoma with central necrosis) so closely mimicking 'DCIS with central comedo necrosis' that on initial morphological analysis these foci of tumors were labeled as DCIS (high grade, comedo). However on further histological work up and by using immunohistochemistry (IHC) for myoepithelial markers it was...
متن کاملAssessment of hormone dependence of comedo ductal carcinoma in situ of the breast.
BACKGROUND Ductal carcinoma in situ (DCIS) represents 20%-30% of breast cancers detected by clinical screening (i.e., mammography). More than 50% of DCIS lesions may be estrogen receptor negative and, therefore, hormone independent. However, the role of estrogen in the natural history of DCIS is unknown. PURPOSE A novel in vivo (i.e., xenograft) model was developed to determine to what degree...
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It is well known that comedo necrosis is closely associated with an aggressive phenotype of ductal carcinoma in situ (DCIS) of human breast, but its molecular mechanisms remain largely unclear. Therefore, in this study, we first examined the gene expression profile of comedo DCIS based on microarray data and identified CYC1 as a gene associated with comedo necrosis. Cytochrome c1 (CYC1) is a su...
متن کاملComputational Model of Ductal Carcinoma In-Situ
Breast cancer, when found in its early stages, is a manageable disease. When detected, biopsied, and diagnosed, lesions such as ductal carcinoma in-situ (DCIS) or invasive ductal carcinoma (IDC) are promptly removed. Consequently, the natural history of DCIS and IDC in-vivo is not well known. DCIS manifests itself with various distinctive patterns and pathologies. In order to study the growth d...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2000
ISSN: 1460-2105,0027-8874
DOI: 10.1093/jnci/92.14.1185a